US Patent 7691564 Heterotrimeric G-protein
Patent 7691564 was granted and assigned to Johns Hopkins University on April, 2010 by the United States Patent and Trademark Office.
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Patent abstract
Receptor mediated activation of heterotrimeric G-proteins is visualized in living cells by monitoring fluorescence resonance energy transfer (FRET) between subunits of a G protein fused to cyan and yellow fluorescent proteins. The G-protein heterotrimer rapidly dissociates and reassociates upon addition and removal of cognate ligand. Energy transfer pairs of G-proteins enables direct in situ detection and have applications for drug screening and GPCR de-orphaning.
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Patent Inventor Names
Chris Janetopoulos0
Peter N. Devreotes0
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US Patent 07691564 Heterotrimeric G-protein US Patent 7691564 Heterotrimeric G-protein
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Patent Number
076915640
Patent Number
76915640
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Infobox
Is a
Current Assignee
Patent Jurisdiction
Patent Number
076915640
Date of Patent
April 6, 2010
0Patent Application Number
113226480
Date Filed
January 3, 2006
0Official Website
Patent Primary Examiner
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US Patent 07691564 Heterotrimeric G-protein
Infobox
Is a
Current assignee
Patent jurisdiction
Patent number
07691564
Date of patent
April 6, 2010
Patent application number
11322648
Date Filed
January 3, 2006
Patent primary examiner
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