US Patent 7691639 Misfolded protein sensor method
Patent 7691639 was granted and assigned to Adlyfe on April, 2010 by the United States Patent and Trademark Office.
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A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
US Patent 07691639 Misfolded protein sensor method US Patent 7691639 Misfolded protein sensor method
US Patent 07691639 Misfolded protein sensor method
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