Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
April 6, 2010
Patent Application Number
11035693
Date Filed
January 14, 2005
Patent Primary Examiner
Patent abstract
This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
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