Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Christian Karsten Hansen0
Hans Thalsgaard Schambye0
Jan Moller Mikkelsen0
Kim Vilbour Andersen0
Torben Lauesgaard Nissen0
Date of Patent
April 13, 2010
0Patent Application Number
114638670
Date Filed
August 10, 2006
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.
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