Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Patrick Gerber0
Agnes Bombrun0
Denis Church0
Date of Patent
April 13, 2010
Patent Application Number
10493066
Date Filed
October 24, 2002
Patent Primary Examiner
Patent abstract
The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of oxindole hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.(I).
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