An optically isolated circuit device includes a first opto-isolator circuit that is driven by a first clock signal, and the output of the first opto-isolator circuit is used to drive a phase-locked loop (PLL) that is configured to synthesize a second clock signal having a frequency that is a multiple of the first clock signal frequency. The second clock signal is used as an input to a suitable clocked circuit of a type that benefits from optical isolation, such as an analog-to-digital converter (ADC).