Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Guriqbal Basi0
Sukanto Sinha0
Lisa McConlogue0
John Anderson0
Date of Patent
May 18, 2010
Patent Application Number
12341336
Date Filed
December 22, 2008
Patent Primary Examiner
Patent abstract
Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protein compositions formed from the purified polypeptides. Methods of screening for compounds that inhibit Aβ using the polypeptides.
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