Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Veronica M. Stellmach0
Olga Volpert0
Paul R. Gillis0
Susan E. Crawford0
David W. Dawson0
Noel P. Bouck0
Date of Patent
May 25, 2010
0Patent Application Number
114943630
Date Filed
July 26, 2006
0Patent Primary Examiner
Patent abstract
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
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