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US Patent 7727749 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids

Patent 7727749 was granted and assigned to Pfizer Limited on June, 2010 by the United States Patent and Trademark Office.

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Patent abstract

The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.

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