A push-button locking pliers has a plurality of macro jaw width stations for grasping a wide variety of objects. A positioning mechanism is connected to a movable jaw member and cooperates with a jaw adjustment slot in the main handle. The positioning mechanism is released by pushing on a push button allowing, it to move along the slot. The user places the positioning mechanism at the jaw positioning station that creates a macro spacing between the fixed and movable jaws that best fits the object to be grasped. An adjustment screw adjusts the micro spacing between the jaws to cause the pliers to lock on the object using an over-center mechanism when the handles are squeezed.