Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Gary R. Petersen0
Stephen V. Lair0
Richard M. Synenki0
Mark D. Cochran0
Date of Patent
June 8, 2010
0Patent Application Number
117344540
Date Filed
April 12, 2007
0Patent Primary Examiner
Patent abstract
The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
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