US Patent 7740880 Polymeric carrier for delivery of small interfering RNA

Patent 7740880 was granted and assigned to University of Utah on June, 2010 by the United States Patent and Trademark Office.

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Patent

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Current Assignee

University of Utah

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

77408800

Patent Inventor Names

Sung Wan Kim0

Won Jong Kim0

Date of Patent

June 22, 2010

Patent Application Number

113672280

Date Filed

March 3, 2006

Patent Primary Examiner

‌

Janet L Epps-Smith

Patent abstract

A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.

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