A device for holding and actuating a sprayer includes a holder and a trigger. The sprayer includes a neck, a rim formed on the neck, a push-button valve and a nozzle provided on the push-button valve. The holder includes a handle, a barrel extending from the handle and a clamp extending from the barrel. The clamp includes two jaws formed thereon, a mouth defined between the jaws and a gap defined between the jaws. The neck of the sprayer can be pushed into the mouth through the gap. The trigger is connected to the holder so that the trigger is operable to push the push-button valve of the sprayer.