Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
June 29, 2010
Patent Application Number
10733212
Date Filed
December 11, 2003
Patent Primary Examiner
Patent abstract
The invention features a method of identifying a compound that inhibits (a) the physical interaction (binding) between MUC1 and tumor progressors (e.g., β-catenin, c-Src, EGF-R, p120ctn, or PKCδ) and/or (b) phosphorylation of MUC1 by tumor progressors with kinase activity (e.g., c-Src, EGF-R, or PKCδ). The invention also includes a method of inhibiting an interaction between MUC1 and β-catenin and a method of inhibiting expression of MUC1 or a tumor progressor in a cell.
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