Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
John S. Blanchard0
Date of Patent
June 29, 2010
0Patent Application Number
105743070
Date Filed
October 1, 2004
0Patent Primary Examiner
Patent abstract
The present invention is directed to a method of identifying an acetyltransferase substrate in a sample that includes the steps of: (a) contacting the sample with (i) a reagent comprising a thiol-containing compound, a halo-acetyl-CoA or a halo-acetyl-pantetheine, and (ii) an acetyltransferase, under conditions suitable for acetyltransferase enzyme activity, and (b) identifying a substrate that has formed a base-stable covalent bond to the reagent, wherein the reagent is labeled with a label and/or the acetyltransferase is labeled with an affinity tag, and the substrate is the acetyltransferase substrate.
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