Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yigal P. Goldberg0
Lan Lin0
Tomas Ganz0
Date of Patent
June 29, 2010
0Patent Application Number
123975890
Date Filed
March 4, 2009
0Patent Primary Examiner
Patent abstract
Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin (s-hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log-linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.
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