Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kallanthottathil G. Rajeev0
Muthiah Manoharan0
Venkitasamy Kesavan0
Date of Patent
June 29, 2010
0Patent Application Number
109161850
Date Filed
August 10, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety. e.g., cholesterol, is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.
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