A device for holding and actuating a can includes a body, a holder and a trigger. The can includes a neck, a rim formed on the neck, a push-button valve and a nozzle installed on the push-button valve. The body includes a handle and a connective portion extended from the handle. The holder is arranged on the connective portion of the body and is formed with two jaws for clipping the neck of the can and for supporting the rim of the can. The trigger is installed on the handle and is formed with a first end to be operated by a user's finger and a second end inserted into the holder for contact with the push-button valve of the can.