Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Miguel Barbosa0
Frank Mercurio0
Hengyi Zhu0
Jian Wu Li0
Brion W. Murray0
Date of Patent
July 20, 2010
0Patent Application Number
118765700
Date Filed
October 22, 2007
0Patent Primary Examiner
Patent abstract
Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.
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