Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Derek L. Stemple0
Colin H. Williams0
Niall A. Armes0
Olaf Piepenburg0
Date of Patent
July 27, 2010
Patent Application Number
12151741
Date Filed
May 7, 2008
Patent Citations Received
Patent Primary Examiner
Patent abstract
This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length.
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