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US Patent 7763592 SHIP-deficiency to increase megakaryocyte progenitor production

Patent 7763592 was granted and assigned to University of South Florida on July, 2010 by the United States Patent and Trademark Office.

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Patent abstract

The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.

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