Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeffrey Schlom0
Syed V S. Kashmiri0
Eduardo A. Padlan0
Date of Patent
July 27, 2010
Patent Application Number
11776437
Date Filed
July 11, 2007
Patent Primary Examiner
Patent abstract
The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain and three light chain) Complementarity Determining Regions (CDRs) of CC49 are present. A second aspect of the invention provides SDR variants of humanized monoclonal antibody (HuCC49) in which only Specificity Determining Regions (SDRs) of at least one CDR from CC49 are present. The invention is also directed towards biotechnological methods of making the variants and therapeutic methods of using the variants.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
