An emplantable pellet comprising one or more pain relief agents. A method to relief pain at the injection site of one or more implanted pharmaceutical pellets comprising the step of implanting one or more of Applicant's implantable pellets. A method to adjust the in vivo rate of release of one or more pain relief agents from Applicants' implantable pellets. A method to adjust the rate of systemic delivery of one or more pharmaceutical agents implanted adjacent one or more of Applicants' implantable pellets.