US Patent 7776309 Preparation and use of alkylating agents
Patent 7776309 was granted and assigned to The Queen's Medical Center on August, 2010 by the United States Patent and Trademark Office.
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Methods of alkylating target compounds are disclosed. The alkylating agent can be radiolabelled. In some instances, the alkylating agent is synthesized and then reacted with a target compound without an intervening purification step. The method comprisesa) synthesizing an alkylating agent having the formula:X—(CR1R2)aCR3R4-LGwherein,a is 0, 1, 2 or 3,R1, R2, R3 and R4 are independently H, X or alkyl,X is a halogen or a label, with the proviso that at least one X is a halogen,LG is a leaving group; andb) directly reacting said alkylating agent with a target compound comprising an alkylation reactive group under conditions suitable for the alkylation of said target compound.
US Patent 07776309 Preparation and use of alkylating agents US Patent 7776309 Preparation and use of alkylating agents
US Patent 07776309 Preparation and use of alkylating agents
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