Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
John E. Shively0
Paul J. Yazaki0
Andrew A. Raubitschek0
Anna M. Wu0
Mark A. Sherman0
Date of Patent
August 17, 2010
0Patent Application Number
118610930
Date Filed
September 25, 2007
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.
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