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US Patent 7776924 Nitroaniline-based alkylating agents and their use as prodrugs

Patent 7776924 was granted and assigned to Auckland Uniservices Limited on August, 2010 by the United States Patent and Trademark Office.

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Patent abstract

Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.

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