Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael D. Parker0
Peter L. Platteborze0
Date of Patent
September 7, 2010
0Patent Application Number
108539520
Date Filed
May 26, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Live attenuated Eastern Equine Encephalitis (EEE) vaccines that outperform the PE-6 vaccine in mice aerosol challenged with >1,000×LD50. Candidates include four furin-cleavage deletion mutants and one E3 deletion mutant. Each vaccine provided protection in birds against antigenically distinct North and South American strains of EEE. The PE-6 vaccine does not provide protection against South American EEEs. Animals inoculated with each of the vaccines of the invention developed neutralizing antibodies to EEE.
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