Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Stephen R. Brych0
Michael Blaber0
Date of Patent
September 7, 2010
0Patent Application Number
110018040
Date Filed
December 2, 2004
0Patent Primary Examiner
Patent abstract
An engineered, purified polypeptide of acidic fibroblast growth factor (FGF-1) is described, the amino acid sequence of which consists essentially of SEQ ID NO: 1. The engineered polypeptide provides 70 times the mitogenic activity of wild type acidic fibroblast growth factor. Other engineered FGFs are also described, having altered properties, including reduced heparin binding affinity and increased mitogenicity as demonstrated with a model mammalian cell line derived from mice, NIH 3T3 fibroblasts.
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