US Patent 7790767 Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
Patent 7790767 was granted and assigned to Nabriva Therapeutics on September, 2010 by the United States Patent and Trademark Office.
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The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3′ are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
US Patent 07790767 Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group US Patent 7790767 Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
US Patent 07790767 Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
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