US Patent 7792647 Quantitatively measuring error causing parameters in fluid handling

A method for quantitatively measuring error causing physical parameters in a fluid handling system, includes: measuring the pressure of air between a piston of a pump and a liquid being handled; detecting a pressure abnormality; determining the time at which the pressure abnormality begins to occur; and based on the time of the pressure abnormality determining the magnitude of the physical parameter causing the pressure abnormality. In a preferred embodiment, the error causing physical parameter is a bubble and the fluid handling is an aspirate operation in a diagnostic analyzer.