Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ziyang Zhong0
Maria Calderon-Cacia0
Stephen D Harrison0
Steve H Nguyen0
Angelica Medina-Selby0
Doris G Coit0
Eric Y Fang0
John A Hall0
Date of Patent
October 5, 2010
0Patent Application Number
120745430
Date Filed
March 3, 2008
0Patent Primary Examiner
Patent abstract
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
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