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US Patent 7811591 Chimeric vaccine for

Patent 7811591 was granted and assigned to Nationwide Children's Hospital on October, 2010 by the United States Patent and Trademark Office.

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Patent abstract

The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.

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