US Patent 7812035 4-substituted piperidines, and methods of use thereof
Patent 7812035 was granted and assigned to Sepracor on October, 2010 by the United States Patent and Trademark Office.
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One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
US Patent 07812035 4-substituted piperidines, and methods of use thereof US Patent 7812035 4-substituted piperidines, and methods of use thereof
US Patent 07812035 4-substituted piperidines, and methods of use thereof
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