An integrated sterilization and materials handling system for sterilizing and handling items such as medical waste, paper, or other things comprises a cart for carrying a removable bin for holding the items to be sterilized, and a sterilization chamber that receives the bin when it is removed from the cart. The various embodiments include a bin that is dumpable with the cart using existing dumping apparatus, a bin that pivots on the cart to permit dumping of the items from the bin by tilting the bin, and a bin used primarily in a dry heat sterilization process of the invention when sterilizing items that are not to be discarded after sterilization to facilitate loading and unloading of the bin. The system has thermal energy booster plates mounted in the sterilization chamber for providing dry radiant heat to the chamber, and the system may vary process times, process pressures, and process temperatures to predetermine settings that correlate to the weight of the items to be sterilized.