Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ronald Vogels0
David Adrianus Theodorus Maria Zuijdgeest0
Menzo Jans Emco Havenga0
Date of Patent
October 19, 2010
0Patent Application Number
113848500
Date Filed
March 20, 2006
0Patent Primary Examiner
Patent abstract
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
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