US Patent 7827983 Method for making a pharmaceutically active ingredient abuse-prevention device

A method of making a pharmaceutically active ingredient abuse-prevention device includes providing a pharmaceutically active ingredient and providing an antagonist of the pharmaceutically active ingredient. The antagonist is in selective fluid communication with the pharmaceutically active ingredient. Electronic circuitry is configured to selectively operate the fluid communication between the antagonist and the pharmaceutically active ingredient so as to mix the pharmaceutically active ingredient with the antagonist upon recognition of one or more predetermined fault conditions. Mixing the pharmaceutically active ingredient with the antagonist renders the pharmaceutically active ingredient substantially ineffective.