Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Laura Segatori0
George Georgiou0
Date of Patent
November 9, 2010
0Patent Application Number
116971140
Date Filed
April 5, 2007
0Patent Primary Examiner
Patent abstract
The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from E. coli FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from E. coli DsbA. Similar to DsbC, such de novo designed chimeric (hybrid) FkpA-DsbA enzymes function, as disulfide reductases, oxidases, or isomerases, and chaperones in vivo and in vitro, despite lacking similarity to DsbC-related polypeptide sequence.
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