US Patent 7833997 Analogs of benzoquinone-containing ansamycins and methods of use thereof

Patent 7833997 was granted and assigned to Infinity Pharmaceuticals on November, 2010 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Infinity Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

78339970

Patent Inventor Names

Yun Gao0

Julian Adams0

Louis Grenier0

Roger H. Pak0

Asimina T. Georges Evangelinos0

James L. Wright0

James R. Porter0

Date of Patent

November 16, 2010

Patent Application Number

121995780

Date Filed

August 27, 2008

Patent Primary Examiner

‌

Bruck Kifle

Patent abstract

The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

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