The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-γ-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.

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US Patent 7838693 Process for the preparation of 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-gamma-lactone

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