A panel for a mattress including first and second fabric layers joined together along their edges and a padding material between said fabrics. The padding material includes at least a layer of resilient foam provided with through-holes. The foam layer is quilted between the first and second fabric layers. A method of manufacturing the panel includes forming a resilient foam body provided with recesses, horizontally cutting a plurality of single layers in the body in the recesses portion to result in at least one layer with through-holes, sandwiching at least one of the single layers provided with through-holes in each panel between the first and second fabric layers.