Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael Brandt0
Apollon Papdimitriou0
Date of Patent
December 7, 2010
0Patent Application Number
118697970
Date Filed
October 10, 2007
0Patent Primary Examiner
Patent abstract
The present invention provides a conjugate consisting essentially of a NK4 molecule and a polyethylene glycol group having a molecular weight of from about 20 to about 40 kDa. The invention also provides a composition in which the monoPEGylated conjugates comprise at least 90% of the total of pegylated NK4 molecules and unpegylated NK4 molecules in the composition. Also provided is a composition in which the monoPEGylated conjugates comprise conjugates in which the PEG groups are attached to groups randomly selected from the lysine side chains of NK4 molecules and the N-terminal amino groups of NK4 molecules. A method for the treatment of cancer by administering 1 to 30 mg monoPEGylated NK4 per kg per day is further provided.
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