Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Vitthal Suryabhan Buchude0
Pramil Kumar Mathur0
Suneel Yeshwant Dike0
Swapnil Shreekant Kore0
Ashok Kumar0
Brajesh Sharma0
Dharmendra Singh0
Nellithanath Thankachen Byju0
Date of Patent
December 7, 2010
0Patent Application Number
126032530
Date Filed
October 21, 2009
0Patent Primary Examiner
Patent abstract
Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.
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