Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Karin Kälin0
Martin A. Billeter0
Pius Spielhofer0
Frank Radecke0
Henriette Schneider0
Date of Patent
December 14, 2010
0Patent Application Number
113204870
Date Filed
December 27, 2005
0Patent Primary Examiner
Patent abstract
The present invention relates, in general, to a methodology or the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
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