Patent 7858635 was granted and assigned to Vertex Pharmaceuticals on December, 2010 by the United States Patent and Trademark Office.
The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.