Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Shigeyuki Iijima0
Takahiro Ishiguro0
Izumi Sugo0
Kiyotaka Nakano0
Masamichi Sugimoto0
Megumi Tanaka0
Date of Patent
January 11, 2011
0Patent Application Number
115779440
Date Filed
October 26, 2005
0Patent Citations Received
Patent Primary Examiner
Patent abstract
An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.
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