Off-die termination of memory module signal lines in a computer memory subsystem. The computer memory subsystem includes a memory controller and a DIMM socket installed on a PCB. The memory controller is electrically coupled to the DIMM socket via a memory module signal line. Off-die termination includes detecting, by a termination controller installed on the PCB, no presence of a DIMM in the DIMM socket and, responsive to the detection, activating, by the termination controller, an off-die termination component on the PCB to terminate the memory module signal line.