Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Daniel T. Dransfield0
Simon E. Hufton0
Rene Hoet0
Clive R. Wood0
Henk Pieters0
Date of Patent
January 18, 2011
Patent Application Number
11049536
Date Filed
February 2, 2005
Patent Primary Examiner
Patent abstract
Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
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