Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ruth Cordoba-Rodriguez0
David M. Frucht0
Date of Patent
January 18, 2011
Patent Application Number
11071799
Date Filed
March 2, 2005
Patent Primary Examiner
Patent abstract
Based on the observation that exposure of cells or animals to anthrax lethal toxin results in activation of the intracellular enzyme caspase-1/IL-1 converting enzyme (ICE), which, in turn, leads to production and extracellular release of the cytokine substrates of ICE: interleukin 1 beta (IL-1β) and interleukin 18 (IL-18), disclosed herein are bioassays that can be used to determine the efficacy of a potential anthrax therapeutic agent and for screening test agents to identify anthrax therapeutic agents. Also disclosed herein are methods of diagnosing and treating anthrax infection.
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