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US Patent 7872107 Interleukin-12p40 variants with improved stability

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Pascal André Stein0

Gordon D. Webster0

Kin-Ming Lo0

Suzanne P. McKenzie0

Date of Patent

January 18, 2011

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Patent Application Number

116476610

Date Filed

December 29, 2006

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Patent Citations Received

US Patent 12103954 Heterodimeric Fc cytokines and uses thereof

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US Patent 11873327 Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof

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Patent Primary Examiner

Bridget E Bunner

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Patent abstract

Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.

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