A safety release adapter for making a sealed fluid connection with a male connector that is disconnected when a pulling force is applied between the adapter and the connector. The safety release adapter includes a base and a socket. The base receives and secures a first male connector. The socket includes a cavity with a lip at the distal end of the socket. The socket releasably secures a second male connector with the lip inside the socket opening engaging a neck of the second male connector. The first male connector extends into the socket in a sealed interface with the socket such that when the second male connector is secured in the socket with a sealed interface with the socket, the valve buttons of each connector are mutually depressed so the two connectors are in sealed fluid communication.